Usage Ayahuasca is used largely as a religious sacrament, no matter which culture it is associated with. Those whose usage of ayahuasca is performed in non-traditional contexts often align themselves with the philosophies and cosmologies associated with ayahuasca shamanism, as practiced among indigenous peoples like the Urarina of Peruvian Amazonia. While non-native users know of the spiritual applications of ayahuasca, a less well-known traditional usage focuses on the medicinal properties of ayahuasca. Its purgative properties are highly important (many refer to it as la Purga, "the purge"). The intense vomiting and occasional diarrhea it induces can clear the body of worms and other tropical parasites,[7] and harmala alkaloids themselves have been shown to be anthelmintic[8]. Thus, this action is twofold; a direct action on the parasites by these harmala alkaloids (particularly harmine in ayahuasca) works to kill the parasites, and parasites are expelled through the increased intestinal motility that is caused by these alkaloids. Ayahuasca cooking in the Napo region of Ecuador. Ayahuasca cooking in the Napo region of Ecuador. Dietary taboos are almost always associated with the use of Ayahuasca; in the rainforest, these tend towards the purification of one's self - abstaining from spicy and heavily seasoned foods, fat, salt, caffeine, acidic foods (such as citrus) and sex before, after, or both before and after a ceremony. A diet low in foods containing tyramine has been recommended, as the speculative interaction of tyramine and MAOIs could lead to a hypertensive crisis. However, evidence indicates that harmala alkaloids act only on MAO-A, in a reversible way similar to moclobemide (a antidepressive that does not require dietary restrictions). Psychonautic experiments and absence of diet restrictions in the highly urban Brazilian ayahuasca church União do Vegetal also suggest that the risk is much lower than conceived, and probably non-existent [9]. Today, the name 'ayahuasca' can mean a variety of botanical concoctions containing one or more MAOIs and DMT or one of its chemical analogues. The synthetic pharmahuasca is sometimes called ayahuasca as well. In this usage, the DMT is generally considered the main psychoactive active ingredient, while the MAOI merely preserves the psychoactivity of orally ingested DMT, which would otherwise be destroyed in the gut before it could be absorbed in the body. Most ayahuasqueros and others working with the brew claim the B. caapi vine to be the defining ingredient; according to them, it is not ayahuasca unless B. caapi is in the brew. The vine is considered to be the "spirit" of ayahuasca, the gatekeeper and guide to the otherworldly realms. In some areas, it is even said that the chakruna or chaliponga admixtures are added only to make the brew taste sweeter. This is a strong indicator of the often wildly divergent intentions and cultural differences between the native ayahuasca-using cultures and psychedelics enthusiasts in other countries. In modern Europe and North America, ayahuasca analogues are often prepared using non-traditional plants which contain the same alkaloids. For example, seeds of the Syrian rue plant are often used as a substitute for the ayawaska vine, and the DMT-rich Mimosa hostilis is used in place of chakruna. Australia has several indigenous plants which are popular among modern ayahuasqueros there, such as various DMT-rich species of Acacia. In modern Western culture, entheogen users sometimes base concoctions on Ayahuasca. When doing so, most often Rue or B. caapi are used with an alternative form of the DMT molecule, such as psilocin, or a non-DMT based hallucinogen such as mescaline. Nicknames such as Psilohuasca, Mush-rue-asca, or 'Shroom-a-huasca, for mushroom based mixtures, or Pedrohuasca (from the San Pedro Cactus, which contains mescaline) are often given to such brews. Such nicknames are by many considered inappropriate and culturally insensitive seeing as "huasca" means "vine" and none of the above are vines, nor do the psychedelic experimentalist trappings of such concoctions bear any resemblance to the medicinal use of Ayahuasca in its original cultural context. This is usually only done by experienced entheogen users who are more familiar with the chemicals and plants being used, as the uninformed combination of various neuro-chemicals can be dangerous. It seems unlikely that Ayahuasca could ever emerge as a "street-drug", given the difficulty of making the tea and the intense experience it provides. Most Western users employ it almost exclusively for spiritual purposes, in line with both traditional, animist usage and organized churches such as the União do Vegetal (or UDV). With the exception of UDV, a diet is almost always followed before use, including a day of fasting. In traditional settings, the "dieta" is followed to spiritually cleanse the body before and after the experience. [edit] Introduction to the West Ayahuasca is mentioned in the writings of some of the earliest missionaries to South America, but it wasn't for some time that it became commonly known in the West. The early missionary reports generally claim it as demonic, and great efforts were made by the Roman Catholic Church to stamp it out. When originally researched in the 20th century, the active chemical constituent of B. caapi was called telepathine, but it was found to be identical to a chemical already isolated from Peganum harmala and given the name harmaline. William Burroughs sought yagé (still considered to be "telepathine") in the 1950s while traveling through South America, in the hopes that it could relieve or cure opiate addiction. The Yage Letters, written between Burroughs and Allen Ginsberg were probably the first major introduction of Ayahuasca to the West. Ayahuasca was made more widely known by Terence and Dennis McKenna's experiences with Amazonian tribes as detailed in the book Invisible Landscape, which they co-authored. Their journey to the rainforest to search for Ayahuasca was spurred by their reading of Burroughs and Ginsberg. Dennis later extensively studied the pharmacology, botany, and chemistry of ayahuasca and oo-koo-he, which were the subjects of his master's thesis. In Brazil, a number of modern religious movements based on the use of ayahuasca have emerged, the most famous of them being Santo Daime and the União do Vegetal (or UDV), usually in an animistic context that may be shamanistic or, more often (as with Santo Daime and the UDV), integrated with Christianity. Both Santo Daime and União do Vegetal now have members and churches throughout the world. Similarly, the US and Europe have started to see new religious groups develop in relation to increased ayahuasca use. PaDeva, an American Wiccan group, has become the first incorporated legal church which holds the use of ayahuasca central to their beliefs. Several notable celebrities have publicly discussed their use of ayahuasca, including Sting, Tori Amos, and Paul Simon (who wrote the song Spirit Voices about his experience with the brew in the Amazon). Some Westerners have teamed up with shamans in the Amazon rainforest regions, forming Ayahuasca healing retreats that claim to be able to cure mental and physical illness and allow communication with the spirit world. Anecdotal reports and scientific studies affirm that ritualized use of ayahuasca may improve mental and physical health,[10] but it poses a potential risk for a psychotic outbreaks in susceptible individuals. [edit] "Ayahuasca tourism" "Ayahuasca tourist" is a pejorative term for those who quest for a transcendent experience through using ayahuasca, implying an insincere Westerner wanting a taste of an exotic ritual, however all Westerners who have teamed up with Amazonian shamans are considered "ayahuasca tourists", or provide modified services geared specifically towards Westerners. Pilgrims and seekers of spiritual knowledge have come to Argentina, Brazil, Colombia, or Mexico have also come for ayahuasca healing as well as explorers of consciousness, writers, medical doctors, journalists, amateur anthropologists and ethnobotanists. The retreats offer the encounter with ayahuasca as an opportunity to re-balance and re-centre their lives, to clear emotional blocks, in a way that has to do with healing and personal evolution. [edit] Initiation Usually a visitor who wishes to becomes a "dietero" or "dietera" that is, a male or female apprentice-shaman learning the way of the teacher plants undergoes a rigorous initiation. This can involve spending a year in the jungle. This initiation challenges and trains the initiate through extreme circumstances covering isolation, deprivation from utilities available in civilization and its conveniences, enduring radical weather of heavy rains, storms, intense heat, insects and solitude.[citation needed] [edit] Modern descriptions Wade Davis (author of The Serpent and The Rainbow) describes the traditional mixture as tough in his book One River: "The smell and acrid taste was that of the entire jungle ground up and mixed with bile." [p.194] Writer Kira Salak describes her personal experiences with ayahuasca in the March 2006 issue of [National Geographic Adventure] magazine. The article includes a candid description of how ayahuasca cured her depression, as well as provides detailed information about the brew. Here is an excerpt from the article about Dr. Charles Grob's landmark findings: The taking of ayahuasca has been associated with a long list of documented cures: the disappearance of everything from metastasized colorectal cancer to cocaine addiction, even after just a ceremony or two. It has been medically proven to be nonaddictive and safe to ingest. Yet Western scientists have all but ignored it for decades, reluctant to risk their careers by researching a substance containing the outlawed DMT. Only in the past decade, and then only by a handful of researchers, has ayahuasca begun to be studied. At the vanguard of this research is Charles Grob, M.D., a professor of psychiatry and pediatrics at UCLA’s School of Medicine. In 1993 Dr. Grob launched the Hoasca Project, the first in-depth study of the physical and psychological effects of ayahuasca on humans. His team went to Brazil, where the plant mixture can be taken legally, to study members of a church, the União do Vegetal (UDV), who use ayahuasca as a sacrament, and compared them to a control group that had never ingested the substance. The studies found that all the ayahuasca-using UDV members had experienced remission without recurrence of their addictions, depression, or anxiety disorders. Unlike most common anti-depressants, which Grob says can create such high levels of serotonin that cells may actually compensate by losing many of their serotonin receptors, the Hoasca Project showed that ayahuasca strongly enhances the body’s ability to absorb the serotonin that’s naturally there. 'Ayahuasca is perhaps a far more sophisticated and effective way to treat depression than SSRIs [antidepressant drugs],' Grob concludes, adding that the use of SSRIs is 'a rather crude way' of doing it. And ayahuasca, he insists, has great potential as a long-term solution.